Mycobacteria That Cause Tuberculosis Have Retained Ancestrally Acquired Genes for the Biosynthesis of Chemically Diverse Terpene Nucleosides.
Mayfield JA, Raman S, Ramnarine AK, Mishra VK, Huang AD, Dudoit S, Buter J, Cheng TY, Young DC, Nair YM, Ouellet IG, Griebel BT, Ma S, Sherman DR, Mallet L, Rhee KY, Minnaard AJ, Branch Moody D. PLoS Biol. 2024 Sep 30; 22(9):e3002813. PMID: 39348416
Lipidomic Scanning of Self-Lipids Identifies Headless Antigens for Natural Killer T Cells.
Cheng TY, Praveena T, Govindarajan S, Almeida CF, Pellicci DG, Arkins WC, Van Rhijn I, Venken K, Elewaut D, Godfrey DI, Rossjohn J, Moody DB. Proc Natl Acad Sci U S A. 2024 Aug 14; 121(34),e2321686121. PMID: 39141352
Human Skin T Cells Express Conserved T Cell Receptors That Cross-React With Staphylococcal Superantigens and CD1a.
Bryan E, Teague JE, Eligul S, Arkins WC, Moody DB, Clark RA, Van Rhijn I. J Invest Dermatol. 2024 Apr; 144(4):833-843.e3. PMID: 37951348
CD1 Lipidomes Reveal Lipid-Binding Motifs and Size-Based Antigen-Display Mechanisms.
Huang S, Shahine A, Cheng TY, Chen YL, Ng SW, Balaji GR, Farquhar R, Gras S, Hardman CS, Altman JD, Tahiri N, Minnaard AJ, Ogg GS, Mayfield JA, Rossjohn J, Moody DB. Cell. 2023 Oct 12; 186(21):4583-4596.e.13. PMID: 37725977
A Terpene Nucleoside From M. Tuberculosis Induces Lysosomal Lipid Storage in Foamy Macrophages.
Bedard M, van der Niet S, Bernard EM, Babunovic G, Cheng TY, Aylan B, Grootemaat AE, Raman S, Botella L, Ishikawa E, O’Sullivan MP, O’Leary S, Mayfield JA, Buter J, Minnaard AJ, Fortune SM, Murphy LO, Ory DS, Keane J, Yamasaki S, Gutierrez MG, van der Wel N, Moody DB. J Clin Invest. 2023 Mar 15; 133(6):e161944. PMID:36757797.
Biotin-Dependent Cell Envelope Remodelling Is Required for Mycobacterium Abscessus Survival in Lung Infection.
Sullivan MR, McGowen K, Liu Q, Akusobi C, Young DC, Mayfield JA, Raman S, Wolf ID, Moody DB, Aldrich CC, Muir A, Rubin EJ. Nature Microbiol. 2023 Mar;8(3):481-497. PMID: 36658396
Staphylococcal Phosphatidylglycerol Antigens Activate Human T Cells via CD1a.
Monnot GC, Wegrecki M, Cheng TY, Chen YL, Sallee BN, Chakravarthy R, Karantza IM, Tin SY, Khaleel AE, Monga I, Uwakwe LN, Tillman A, Cheng B, Youssef S, Ng SW, Shahine A, Garcia-Vilas JA, Uhlemann AC, Bordone LA, Han A, Rohde CH, Ogg G, Moody DB, Rossjohn J, de Jong A. Nature Immunol. 2023 Jan;24(1):110-122.PMID: 36550321
Atypical Sideways Recognition of CD1a by Autoreactive Γδ T Cell Receptors.
Wegrecki M, Ocampo TA, Gunasinghe SD, von Borstel A, Tin SY, Reijneveld JF, Cao TP, Gully BS, Le Nours J, Moody DB, Van Rhijn I, Rossjohn J. Nature Commun. 2022 Jul 5;13(1):3872. PMID: 35790773
Single-Cell eQTL Models Reveal Dynamic T Cell State Dependence of Disease Loci.
Nathan A, Asgari S, Ishigaki K, Valencia C, Amariuta T, Luo Y, Beynor JI, Baglaenko Y, Suliman S, Price AL, Lecca L, Murray MB, Moody DB, Raychaudhuri S. Nature. 2022 Jun;606(7912):120-128. PMID: 35545678
CD1a Selectively Captures Endogenous Cellular Lipids That Broadly Block T Cell Response.
Cotton RN, Wegrecki M, Cheng TY, Chen YL, Veerapen N, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis R, Altman JD, de Jong A, Van Rhijn I, Clark RA, Besra GS, Ogg G, Rossjohn J, Moody DB. J Exp Med. 2021 Jul 5;218(7):e20202699. PMID: 33961028
Human Skin Is Colonized by T Cells That Recognize CD1a Independently of Lipid.
Cotton RN, Cheng TY, Wegrecki M, Le Nours J, Orgill DP, Pomahac B, Talbot SG, Willis RA, Altman JD, de Jong A, Ogg G, Van Rhijn I, Rossjohn J, Clark RA, Moody DB. J Clin Invest. 2021 Jan 4;131(1):e140706. PMID: 33393500
Human γδ T Cells Recognize CD1b by Two Distinct Mechanisms.
Reijneveld JF, Ocampo TA, Shahine A, Gully BS, Vantourout P, Hayday AC, Rossjohn J, Moody DB, Van Rhijn I. Proc Natl Acad Sci U S A. 2020 Sep 15;117(37):22944-22952. PMID: 32868441
Discovery of Salmonella Trehalose Phospholipids Reveals Functional Convergence with Mycobacteria.
Reinink P, Buter J, Mishra VK, Ishikawa E, Cheng TY, Willemsen PTJ, Porwollik S, Brennan PJ, Heinz E, Mayfield JA, Dougan G, van Els CA, Cerundolo V, Napolitani G, Yamasaki S, Minnaard AJ, McClelland M, Moody DB, Van Rhijn I. J Exp Med. 2019 Apr 1;216(4):757-771. PMID: 30804000